The yjeQ gene is required for virulence of Staphylococcus aureus.
نویسندگان
چکیده
Gene products required for in vivo growth and survival of Staphylococcus aureus and other pathogens represent new targets for antimicrobial chemotherapy. In this study we created a Staphylococcus aureus yjeQ deletion strain and tested its virulence using a mouse kidney abscess infection model. The yjeQ deletion strain was compromised for growth in vitro and severely attenuated for virulence. We concluded that yjeQ is an attractive and novel new drug target.
منابع مشابه
Association of agr Gene Expression with Staphylococcus Aureus Virulence Genes in BHI Broth
Abstract Background and Objective: Agr is the most important regulatory system for the expression of Staphylococcus aureus virulence factors in different conditions. Agr acts as a quorum sensing system in this bacterium which is activated by increased cell concentration during the transition from logarithmic growth phase to stationary phase. Its role is to up...
متن کاملIdentification of Virulence Genes in Staphylococcus aureus Isolates Segregated from Children’s Wounds
Background: Staphylococcus aureus is an opportunistic pathogenic bacterium that can provide invasive conditions by secreting various toxins. It is involved in the development of skin infections, such as swollen and ulcers. Today, one of the main problems is the treatment of Staphylococcus aureus resistant strains. The aim of the current study was to detect virulence factors and antibiotic re...
متن کاملIdentification of Toxic Shock Syndrome Toxin-1 (TSST-1) gene in Staphylococcus aureus isolated from bovine mastitis milk
Staphylococcus aureus is a major causative pathogen of clinical and subclinical mastitis of dairy domestic ruminants. This agent produces a variety of extracellular toxins and virulence factors including Toxic Shock Syndrome Toxin-1 (TSST-1) which is the major cause of Toxic Shock Syndrome (TSS). In this study 58 S. aureus isolates obtained from 9 dairy herds in East and West Azerbaijan provinc...
متن کاملشناسایی ژن‌های حدت پنتون والنتین لوکوسیدین (PVL) و مقاومت به متی‌سیلین (mecA ) در استافیلوکوکوس اورئوس جدا شده از نمونه‌های بالینی: یک گزارش کوتاه
Background and Objective: Staphylococcus aureus is a major pathogen of human in the world. Methicillin-resistant Staphylococcus aureus is associated with nosocomial infections. Recently, staphylococcal infections have been associated with the community. The purpose of this study was to isolate and identify Staphylococcus aureus virulence Panton-Valentine leukocidin (PVL) and methicillin...
متن کاملSurvey of accessory gene regulator (agr) groups and TSST-1 encoding gene (tst) in Staphylococcus aureus isolated from ewes with mastitis in the northwest of Iran
Accessory gene regulator (agr locus) is a global regulator of many virulence gene expressions inStaphylococcus aureus. Four interference classes related to genetic polymorphisms in the agr locus have sofar been described. In the present study, the agr locus specificity groups were studied within a total of 43 S.aureus isolates which were isolated from ewes with mastitis in three regions in the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Infection and immunity
دوره 74 8 شماره
صفحات -
تاریخ انتشار 2006